32P Therapy of Chronic Granulocytic Leukemia

Intensive leukapheresis as initial therapy for chronic granulocytic leukemia.

Intensive leukapheresis has been used as the initial treatment of chronic granulocytic leukemia (CGL) in six patients. The number of leukaphereses ranged from 3 in 7 days to 13 in 39 days (mean, 8 in 22 days). The procedures were well tolerated, and in all patients there was improvement in hematologic values, in most cases with considerable reduction in the peripheral leukocytosis and thrombocy...

Myelofibrosis in chronic granulocytic leukemia.

In 181 patients with chronic granuloMF with CCL was associated with three cytic leukemia (CGL) 39 patients demonfindings: (1) elevation of the leukocyte strated myelofibrosis (MF) during the alkaline phosphatase, (2) a very poor course of their disease. These groups prognosis and (3) the frequent associacan be divided into two groups: one tion of MF and blastic transformation of group initially...

Megakaryoblastic transformation of chronic granulocytic leukemia.

Three cases of megakaryoblastic transformation of chronic granulocytic leukemia (CGL) are reported. In each case, the leukemic transformation had morphologic features suggesting megakaryocytic differentiation. This was confirmed by positive immunostaining with a monoclonal antibody (HP1-1D) specific for platelet and megakaryocyte glycoprotein IIb/IIIa antigen, which was expressed by the majorit...

Autoimmune hemolytic anemia in chronic granulocytic leukemia.

A UTOIMMUNE HEMOLYTIC ANEMIA may complicate a wide variety of diseases, among which are infectious diseases, “collagen” diseases, benign tumors, malignant tumors, lymphomas and Hodgkin’s disease.1’2 The lymphoproliferative disorders, especially chronic lymphatic leukemia, have often been associated with abnormal immunologic mechanisms. The myeloproliferative disorders are rarely associated with...

Chronic granulocytic leukemia and the Philadelphia chromosome.